Mechanistic Study of Prenylated Flavin Mononucleotide Formation
نویسندگان
چکیده
منابع مشابه
The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis
The UbiD family of reversible decarboxylases act on aromatic, heteroaromatic, and unsaturated aliphatic acids and utilize a prenylated flavin mononucleotide (prFMN) as cofactor, bound adjacent to a conserved Glu-Arg-Glu/Asp ionic network in the enzyme's active site. It is proposed that UbiD activation requires oxidative maturation of the cofactor, for which two distinct isomers, prFMNketimine a...
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We examined the effects of caffeic acid (CA) and related compounds on 7-carboxyheptyl radical formation. This analysis was performed using a standard D2O reaction mixture containing 4.3 mM oleic acid, 25 μM flavin mononucleotide (FMN), 160 mM phosphate buffer (pH 7.4), 10 mM cholic acid, 100 mM α-(4-pyridyl-1-oxide)-N-tert-butylnitrone, and 1 mM Fe(SO4)2(NH4)2 during irradiation with 7.8 J/cm2 ...
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Several D P N H dehydrogenases have been purified from heart mitochondria or heart-muscle preparationsl-L STRAUB'S enzym& has been shown by MASSEY 8 to be a form of lipoamide dehydrogenase (EC 1.6.4.3), while the relationship of the remaining preparations to the respiratory chain and to each other is obscure. The flavin extractable by acid t reatment has been reported to be FMN in some casesl, ...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.393